Christine M Toedebusch

Christine M Toedebusch

Associate Professor

Molecular Biosciences
Surgical & Radiological Sciences


Licenses
Diplomate American College of Veterinary Internal Medicine - Neurology
California State Veterinary License
Education
2010, DVM, University of Wisconsin, Madison, WI
2011, Internship, Veterinary Specialty Hospital, San Diego, CA
2012, Fellow, University of Missouri, Columbia, MO
2017, PhD, University of Missouri, Columbia, MO
2018, Residency, University of Missouri, Columbia, MO
Active Research Grants
Co-Investigator, Placental-Derived Natural Killer (NK) Cells to Target High Grade Gliomas in Dogs, Canter (Principal Investigator), UC Davis Schools of Medicine and Veterinary Medicine
Co-Principal Investigator, Olfactomedin-like 3: A novel drug target and delivery system to improve glioblastoma outcomes, Yuanpei Li (Principal Investigator), UC Davis Comprehensive Cancer Center
Co-Principal Investigator, The creation of canine cancer genome atlas, John McPherson (Principal Investigator), UC Davis Comprehensive Cancer Center
Co-Investigator, Extracellular Vesicle Theranostics in the Central Nervous System, George (Principal Investigator), UC Davis Health: Cultivating Team Science
Principal Investigator, The role of olfactomedin-like 3 in glioma progression. Paul Calabresi K12 Career Development Award, (Principal Investigator), National Cancer Insitute
Co-Investigator, Magnetofluorescent nanoplatform for glioblastoma therapy, Yu, Perez (Principal Investigator), National Cancer Institute
Principal Investigator, Canine Cancer Genome Atlas Biobanking Resources, (Principal Investigator), UC Davis CTSC
Principal Investigator, Placental-Derived Natural Killer (NK) Cells to Improve Outcomes for Canine High Grade Gliomas, (Principal Investigator), Center for Companion Animal Health
Research Focus
Neuroimmunology and the role of microglia in canine and feline CNS health and disease, with a specific focus on the role of microglia in primary brain tumorigenesis.
Specialty Focus
Neurology & Neurosurgery
Ten Recent Publications

2024
Zakimi N, Mazcko CN, Toedebusch CM, Tawa G, Woolard K, LeBlanc AK, Dickinson PJ, Raleigh DR
Canine meningiomas are comprised of 3 DNA methylation groups that resemble the molecular characteristics of human meningiomas.

2024
Razmara AM, Gingrich AA, Toedebusch CM, Rebhun RB, Murphy WJ, Kent MS, Canter RJ
Improved characterization and translation of NK cells for canine immunotherapy

2023
Mathews K, Toedebusch C, Palm C, Kendall A, Westropp JL
Idiopathic Functional Urinary Outflow Tract Obstruction in dogs, a retrospective case series (2010-2021): 31 cases

2023
Toedebusch RG, Wei NW, Simafranca KT, Furth-Jacobus JA, Brust-Mascher I, Stewart SL, Dickinson PJ, Woolard KD, Li CF, Vernau KM, Meyers FJ, Toedebusch CM^
Intra- and Intertumoral Microglia/Macrophage Infiltration and Their Associated Molecular Signature Is Highly Variable in Canine Oligodendroglioma: A Preliminary Evaluation

2022
Joseph LM, Toedebusch RG, Debebe E, Bastian AH, Lucchesi CA, Syed-Quadri S, Wittenburg LA, Chen X, Meyers FJ, Toedebusch CM^
Microglia-Derived Olfactomedin-like 3 Is a Potent Angiogenic Factor in Primary Mouse Brain Endothelial Cells: A Novel Target for Glioblastoma.

2022
Kent MS, Karchemskiy S, Culp WTN, Lejeune AT, Pesavento PA, Toedebusch C, Brady R, Rebhun R
Longevity and mortality in cats: A single institution necropsy study of 3108 cases (1989-2019).

2022
Razmara AM, Wittenburg LA, Al-Nadaf S, Toedebusch RG, Meyers FJ, Toedebusch CM^
Prevalence and Clinicopathologic Features of Canine Metastatic Melanoma Involving the Central Nervous System: A Retrospective Analysis and Comparative Review.

2021
Murthy VD, Li CF, Hicks J, Kroll J, Giuffrida M, Dickinson P, Toedebusch CM^
Serum phosphorylated neurofilament heavy chain as a diagnostic biomarker for progressive myelomalacia in dogs with thoracolumbar intervertebral disc herniation

2021
Toedebusch RG, Grodzki AC, Dickinson PJ, Woolard K, Vinson NM, Sturges B, Snyder J, Li CF, Nagasaka OM, Consales BM, Vernau K, Knipe M, Murthy V, Lein PJ, Toedebusch CM^
Glioma-associated microglia/macrophages augment tumorigenicity in canine astrocytoma, a naturally occurring model of human glioma

2021
Toedebusch RG, Lucchesi CA, Debebe ET, Wittenburg LA, Chen X, Toedebusch CM^
Microglia-Derived Olfactomedin-like 3 Promotes Pro-Tumorigenic Microglial Function and Malignant Features of Glioma Cells.