Reproductive Biology
Pouya Dini, DVM, PhD, PhD, Dipl. ECAR, Dipl. ACT
Assistant Professor in Equine Reproduction
Department of Population Health and Reproduction (PHR)
(see also: Translational Research, Microbiology)
Research Interests: My research topics include parental gene expression in the placenta and the reciprocal paternal and maternal gene interaction in the equine's placental development and its pathologies, effects of assisted reproductive techniques on the epigenetic of the equine placenta, and host-pathogen interaction during equine placentitis. We use high-throughput sequencing along with classical molecular and cellular biology techniques to explore these topics.
Possible learning outcomes:
1- Culture cells and organoid from reproductive tract (mainly equine)
2- Extract nucleotides and PCR
3- Get familiar with next-generation Sequencing methods
4- Get familiar with in vitro embryo production in equine and bovine
Dr. Dini can be reached via email at pdini@ucdavis.edu.
Ghislaine Dujovne, DVM, MS
Assistant Professor in Clinical Theriogenology
VMTH
Dr. Dujovne is a theriogenologist whose clinical work focuses mainly in equine reproduction. Dr. Dujovne's research interests focus on reproductive problems of clinical relevance on mares and stallions. Dr Dujovne’s main interest is efficient clinical management of reproductive diseases and artificial reproductive techniques. She has participated in research related with estrus suppression in performance mares, endometritis treatment in mares, stallion semen quality, post-mortem sperm recovery in stallions and semen evaluation in canine semen.
CONTACT EMAIL: gadujovne@ucdavis.edu
Pascal Gagneux, Ph.D.
Affiliated with UC Veterinary Medical Center – San Diego
(See also: Biochemistry/Cell Biology)
Dr. Gagneux is interested in primate molecular diversity. His lab investigates the evolutionary mechanisms responsible for the generation and maintenance of primate diversity, its potential roles in protecting populations from pathogens as well as potential consequences for reproductive compatibility. He is currently studying cell-surface molecules of sperm cells in closely related primate species. His focus is on glycans, the oligosaccharides attached to glycolipids and glycoproteins of the cell surface. The numerous parallels between the surface molecules of successful pathogens and those found on the surface of mammalian sperm, invite the analogy between internal fertilization and “extremely successful infection”. These interests examine the differences in sperm surface molecules and sexual selection (via sperm competition and cryptic female choice) and whether such differences might contribute to reproductive incompatibility and speciation due to female immune rejection of sperm with incompatible glycoconjugates. Dr. Gagneux has studied the behavioral ecology of wild chimpanzees in the Taï Forest, Ivory Coast, population genetics of West African chimpanzees, and differences in sialic acid biology between humans and great apes with special consideration of their differing pathogen regimes. His great concern is that the current surge in interest for comparative genomics is not being translated into direct support for the conservation of primates in their endangered natural habitats.
Please contact Peter Ernst pernst@ucsd.edu or Christina Sigurdson csigurdson@ucsd.edu first for more information.
Fabio Lima, DVM, MS, PhD, DACT
VM: Population Health & Reproduction
(See also: Food Animal Medicine & Food Safety)
The overarching goal of my research program is to promote the sustainability of dairy farming and help safeguard the food supply for humankind.
Summer research students are welcome to participate in the following projects:
1) Integrating host and microbial genomics and machine learning to predict metritis cure and reduce antimicrobial use in dairy cows: In this project students will be able to learn foundational principles of herd health monitoring diseases, diagnosis diseases, and how use genotypical, phenotypical, and microbial data to improve judicious use of antimicrobial use. This project involve visiting commercial dairy farms routinely, collect samples, data, and process samples in the laboratory.
2) Unraveling nerve growth factor-ß role on hypothalamic pituitary ovarian axis in cattle: On this project students will have an opportunity to learn to improving their handling skills in cattle, post procedure monitoring of calves, collect blood and cerebral fluids samples to learn, collect samples for trancriptome analysis, learn how to use ultrasonography examination imaging to characterize ovarian dynamics in regulated estrous cycle.
Dr. Lima can be reached at falima@ucdavis.edu.
Stuart Meyers, DVM, PhD
Reproduction, aging and sperm physiology and cryopreservation, male effects on embryo development, and germ cell transplantation in endangered fish
VM: Anatomy, Physiology & Cell Biology
Dr. Meyers is a veterinarian, professor, and researcher in the SVM with special interest in reproduction. Research in our laboratory has centered on gamete cryopreservation and an understanding of the role of the paternal genome on embryo development and fertility. Our newest research area is germ cell transplantation of endangered fish into surrogate non-endangered species. Our study models are the rhesus monkey, stallion, dog, and endangered fish. Our goals are to develop an understanding of fundamental mechanisms of cellular damage caused by low temperature storage, and then to use this knowledge to develop new methods for gamete preservation and subsequent fertility. We use a variety of techniques including flow cytometry and confocal, fluorescence, and electron microscopy to evaluate the integrity of sperm cell organization and cell function.
Dr. Meyers can be reached via email at smeyers@ucdavis.edu.